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Zollinger Ellison Syndrome - Zollinger Ellison Syndrome symptom, treatment, causes

Zollinger Ellison Syndrome is an uncommon disorder characterised by excessive secretion of acid and pepsin (protein-digesting enzyme) by the lining of the stomach. It leads to severe and recurrent PEPTIC ULCER DISEASE in the Zoonosis stomach. duodenum (first part of the small intestine) and upper part of the small intestine. The syndrome results from the presence of one or more tumours in the pancreas that produce the hormone gastrin. which stimulates stomach secretions. The cause of these tumours is unknown. but the condition is often associated with other endocrine gland disorders, particularly of the parathyroid glands, which control body calcium.

Zollinger-Ellison syndrome is a condition caused by abnormal production of the hormone gastrin. A small tumor (gastinoma) in the pancreas or small intestine produces the high levels of gastrin in the blood. These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes excessive production of acid by your stomach. The excess acid, in turn, leads to peptic ulcers. The ulcers that occur as part of Zollinger-Ellison syndrome are often numerous, tend to occur in unusual areas of your stomach or intestine and are more resistant to treatment than other ulcers are. They are also likely to return after being treated. Zollinger-Ellison syndrome is rare, and though it may occur at any age, people between the ages of 30 and 60 are more likely to develop it. Also, of all the people who suffer with a peptic ulcer, only a tiny percentage of those people will have Zollinger-Ellison.

Zollinger Ellison Syndrome is an uncommon disorder characterised by excessive secretion of acid and pepsin (protein-digesting enzyme) by the lining of the stomach. It leads to severe and recurrent peptic ulcer disease in the Zoonosis stomach. Duodenum (first part of the small intestine) and upper part of the small intestine. The cause of these tumours is unknown. The symptoms of ZES include signs of peptic ulcers: gnawing, burning pain in the abdomen; diarrhea; nausea; vomiting; fatigue; weakness; weight loss; and bleeding. Physicians diagnose ZES through blood tests to measure levels of gastrin and gastric acid secretion. They may check for ulcers by doing an endoscopy, which involves looking at the lining of the stomach and duodenum through a lighted tube. The primary treatment for ZES is medication to reduce the production of stomach acid. Proton pump inhibitors that suppress acid production and promote healing are the first line of treatment and include lansoprazole, omeprazole, pantoprazole, and rabeprazole. H-2 blockers such as cimetidine, famotidine, and ranitidine may also be used, but may be less effective in reducing stomach acid. Surgery to treat peptic ulcers or to remove tumors in the pancreas or duodenum are other treatment options. People who have been treated for ZES should be monitored in case the ulcers or tumors recur.

Symptom of Zollinger Ellison Syndrome

Symptoms are those of peptic ulcer disease, often with complications such as perforation of the stomach or duodenum. bleeding and gut obstruction. The diagnosis of Zollinger-Ellison syndrome is confirmed by finding abnormally high levels of gastrin in the blood. Some common Symptoms of Zollinger Ellison Syndrome :

• Diarrhea.
• Abdominal pain.
• Weight loss.
• Epigastric pain (stomachache) that goes away with consumption of foods.
• Nausea and vomiting
• Weakness.
• Fatigue.
• Difficulty in eating.
• Vomiting blood (hematemesis) (occasional).
• Yellow fat in stool.

Causes of Zollinger Ellison Syndrome

The common Causes of Zollinger Ellison Syndrome :

• The tumors secrete a hormone called gastrin that causes the stomach to produce too much acid, which in turn causes stomach and duodenal ulcers.
• Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea .
• The excessive acid then leads to peptic ulcers and sometimes to diarrhea.
• Gastrin works on stomach parietal cells causing them to secrete more hydrogen ions into the stomach lumen.

Treatment of Zollinger Ellison Syndrome

Treatment with drugs that reduce stomach secretions will relieve symptoms and lead to healing of ulcers. but if possible the tumours are removed to eliminate the syndrome.

• Using chemotherapy to try to slow tumor growth.
• Injecting drugs into the tumor to relieve cancer symptoms.
• Removing as much of a liver tumor as possible (debulking).
• Stop an ulcer from bleeding.
• Close up the hole (perforation) that an ulcer has made in the wall of your stomach or duodenum.
• Attempting to destroy the tumor by cutting off the blood supply (embolization) or by using heat to destroy cancer cells (radio frequency ablation) .