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Nafarelin Acetate - Learn about Nafarelin Acetate Side Effects and Precautions

Nafarelin Acetate Information

The pharmacology action of Nafarelin Acetate is that it initially causes synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continued use (more than 4 wk) suppresses secretion of LH and FSH.

Nafarelin Acetate is used in treatment of endometriosis, central precocious puberty in children of both sexes. .

Interaction and Contraindication of Nafarelin Acetate

Interaction of Nafarelin Acetate - Not available

Contraindication of Nafarelin Acetate - Hypersensitivity to gonadotropin-releasing hormone (GnRH); or GnRH-agonist analogs; undiagnosed abnormal vaginal bleeding; pregnancy; lactation

Side Effects o f Nafarelin Acetate

Here are the list of some common side effects ofNafarelin Acetate :

• Headaches; insomnia; depression
• Acne; seborrhea
• Nasal irritation
• Hot flushes; decreased libido; emotional lability; myalgia; reduced breast size; edema; weight gain; hirsutism; decreased bone density

Precaution and Warning while taking Nafarelin Acetate

The precaution and warnings of Nafarelin Acetate drug is as follows:

• Caution patient that this medication must not be taken during pregnancy or when pregnancy is possible. Advise patient to use nonhormonal form of birth control while taking this drug.
• Advise patient regarding proper administration techniques and storage information.
• Tell patient to begin treatment between days 2 and 4 of menstrual cycle if being treated for endometriosis.
• Instruct patient not to blow nose, and to avoid sneezing immediately after administration.
• Tell patient using topical nasal decongestant to use 2 hr after nafarelin has been administered.
• Advise patient that each bottle contains about 60 sprays and plan refills accordingly.
• Explain side effects of medication and instruct patient to report the following symptoms to health care provider: bleeding/menses continues, breakthrough bleeding or adverse/side effects.

How to store Nafarelin Acetate

• When treating endometriosis, begin treatment between days 2 and 4 of menstrual cycle.
• Administer intranasally with metered-spray pump. Patient's head should be tilted back slightly.
• If administering more than 1 spray per nostril, wait 30 sec between sprays.
• Store container upright at room temperature (59° to 86°F).
• Protect from light.