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Nadolol - Learn about Nadolol Side Effects and Precautions

Nadolol Information

The pharmacology action of Nadolol is that it blocks beta-receptors, which primarily affect cardiovascular system (decreases heart rate, contractility, and BP) and lungs (promotes bronchospasm).

Nadolol is used in treatment of hypertension and angina pectoris

Interaction and Contraindication of Nadolol

Interaction of Nadolol - Clonidine:  May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal.
Epinephrine:  Initial hypertensive episode followed by bradycardia may occur.
Ergot derivatives:  Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur.
Insulin:  Prolonged hypoglycemia with masking of symptoms may occur.
Lidocaine:  Lidocaine levels may increase, leading to toxicity.
NSAIDs:  Some agents may impair antihypertensive effect.
Prazosin:  Orthostatic hypotension may be increased.
Verapamil:  Effects of both drugs may be increased.

Contraindication of Nadolol - Hypersensitivity to beta-blockers; greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers or untreated hypotension; overt cardiac failure; sinus bradycardia; cardiogenic shock; bronchial asthma or bronchospasm, including severe COPD.

Side Effects o f Nadolol

Here are the list of some common side effects ofNadolol :

• Bradycardia; hypotension; CHF; cold extremities; heart block; worsening angina; edema
• Depression; fatigue; lethargy; drowsiness; short-term memory loss; headache; dizziness
• Dry eyes; visual disturbances
• Nausea; vomiting; diarrhea
• May increase or decrease blood glucose; elevated triglycerides and total cholesterol; decreased HDL cholesterol
• Wheezing; bronchospasm; difficulty breathing
• Increased sensitivity to cold

Precaution and Warning while taking Nadolol

The precaution and warnings of Nadolol drug is as follows:

• Ensure that patient has independently demonstrated how to measure pulse rate.
• Show patient how to monitor blood sugar levels, and explain that signs and symptoms of low blood sugar levels may be masked.
• Caution patient not to stop taking medication abruptly but to consult health care provider for instructions on safest way to discontinue medication.
• Instruct patient to report the following symptoms to health care provider: bradycardia, palpitations, dizziness, fatigue, insomnia or sleep disturbances, altered sensorium, GI symptoms, and changes in blood sugar levels.
• Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
• Instruct patient not to take OTC medications without consulting health care provider .

How to store Nadolol

• Assess heart rate and BP before administering medication.
• Administer on regular schedule.
• Give medication with full glass water, either with or without food.
• Discontinue drug gradually over 1 to 2 wk.
• Store in tightly closed, light-resistant container at room temperature (59° to 86°F).