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Nabumetone - Learn about Nabumetone Side Effects and Precautions

Nabumetone Information

The pharmacology action of Nabumetone is that it decreases inflammation, pain and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Nabumetone is used in treatment of chronic and acute rheumatoid arthritis and osteoarthritis.

Interaction and Contraindication of Nabumetone

Interaction of Nabumetone - Anticoagulants:  May increase effect of anticoagulants. May increase risk of gastric erosion and bleeding.
Cyclosporine:  Neurotoxicity of both agents may be increased.
Lithium:  May increase lithium levels.
Methotrexate:  Increased risk of methotrexate toxicity.
Salicylates:  Additive GI toxicity.

Contraindication of Nabumetone - Hypersensitivity to aspirin, iodides, or any NSAID.

Side Effects o f Nabumetone

Here are the list of some common side effects ofNabumetone :

• Edema; weight gain; congestive heart failure; alterations in BP; vasodilation; palpitations; tachycardia; chest pain; bradycardia
• Dizziness; lightheadedness; drowsiness; confusion; increased sweating; vertigo; headaches; nervousness; migraine; anxiety; aggravated Parkinson or epilepsy; paresthesia; peripheral neuropathy; myalgia; tremors; fatigue.
• Blurred vision; tinnitus; rhinitis; salivation; glossitis; pharyngitis.
• Diarrhea; ulceration; dry mouth; heartburn; dyspepsia; nausea; vomiting; anorexia; diarrhea; constipation; flatulence; indigestion; appetite changes; abdominal cramps; epigastric pain; hematemesis; peptic ulcer; stomatitis
• Acute renal insufficiency; interstitial nephritis; hyperkalemia; hyponatremia; papillary necrosis; melena; menometrorrhagia; impotence; menstrual disorders; hematuria; cystitis; nocturia; proteinuria.

Precaution and Warning while taking Nabumetone

The precaution and warnings of Nabumetone drug is as follows:

• Explain that therapeutic effects may take up to 1 mo to be noted.
• Instruct patient to report the following symptoms to health care provider: rash, visual disturbance, ringing in ears, dark stools, persistent headache or abdominal pain, unusual bleeding or bruising, decreased urinary output, weight gain, edema.
• Caution patient to avoid intake of alcoholic beverages and to avoid smoking.
• Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
• Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction

How to store Nabumetone

• Give medication with full glass of water, either with or without food.
• Store in tightly closed, light-resistant container at room temperature (59° to 86°F).