|
|
|
Home :: Drugs :: Labetalol
Labetalol - Learn about Labetalol Side Effects and Precautions
Labetalol Information
The pharmacology action of Labetalol is that it
selectively blocks alpha-1 receptors and nonselectively blocks beta-receptors to decrease BP, heart rate, and myocardial oxygen demand.
Labetalol is used
in
treatment of hypertension.
| Labetalol Class |
Alpha-adrenergic blocker/Beta-adrenergic blocker |
| How Labetalol Supplied |
Normodyne Tablets 100 mg , Tablets 200 mg , Tablets 300 mg , Injection 5 mg/mL
Trandate Tablets 100 mg , Tablets 200 mg , Tablets 300 mg , Injection 5 mg/mL |
| Brand Name : |
Apo-Labetalol |
Interaction and Contraindication of Labetalol
Interaction of Labetalol -
Beta-adrenergic agonists: Blunted bronchodilator effect.
Cimetidine: Increased bioavailability of labetalol.
Indomethacin: Impaired antihypertensive effect of labetalol.
Inhalation anesthetics: May exaggerate hypotension.
Nitroglycerin: Increased hypotension.
Contraindication of Labetalol -
Severe bradycardia; second- and third-degree heart block; heart failure; cardiogenic shock; bronchial asthma.
Side Effects o f Labetalol
Here are the list of some common side effects ofLabetalol :
- Orthostatic hypotension; edema; flushing; ventricular arrhythmias; AV block; bradycardia; heart failure; chest pain.
- Headache; fatigue; dizziness; depression; lethargy; drowsiness; forgetfulness; sleepiness; vertigo; paresthesia; nightmares.
- Dry eyes; visual disturbances; altered taste perception.
- Nausea; vomiting; diarrhea; dyspepsia
- Bronchospasm; shortness of breath; wheezing
- Muscle cramps; systemic lupus erythematosus; increased hypoglycemic response to insulin; masking of hypoglycemic signs; asthenia
Precaution and Warning while taking Labetalol
The precaution and warnings of Labetalol drug is as follows:
- Advise patient to notify dentist and other health care providers of drug therapy before treatment or surgery.
- Caution diabetic patient to monitor serum glucose carefully.
- Instruct patient to not discontinue drug abruptly.
- Advise patient to carry identification (eg, Medi-Alert ) indicating medical condition and drug regimen.
- Instruct patient how to measure BP and pulse.
- Emphasize importance of the following other modalities on BP: weight control, regular exercise, smoking cessation and moderate intake of alcohol and salt.
- Inform patient that transient scalp tingling may occur, especially when treatment is initiated.
- Instruct patient to report the following symptoms to health care provider: slow heart rate, dizziness, confusion, fever or depression, shortness of breath, fatigue, swelling of ankles and feet.
- Advise patient that drug causes dizziness and to use caution while driving or performing other tasks requiring mental alertness.
How to store Labetalol
- Administer oral form with food; tablets can be crushed.
- If nausea and dizziness occur with twice-daily dosing of oral form, same total daily dose can be administered as divided doses 3 times/day.
- Keep patient supine during IV administration and for 3 hr afterward.
- For repeated IV injection, give 20 mg dose slowly over 2 min.
- Store at room temperature and protect from excessive moisture.
- Do not freeze injection vials. Protect from light. Parenteral solution is stable for 24 hr after dilution.
|
|
