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Home :: Drugs :: Ketorolac Tromethamine
Ketorolac Tromethamine - Learn about Ketorolac Tromethamine Side Effects and Precautions
Ketorolac Tromethamine Information
The pharmacology action of Ketorolac Tromethamine is that it
decreases inflammation, pain, and fever through inhibition of prostaglandin synthesis.
Ketorolac is contraindicated in patients with advanced renal impairment and in patients at risk for renal failure because of volume depletion. Adjust dose for patients with moderately elevated serum creatinine.
Ketorolac Tromethamine is used
in
treatment
of
moderately severe, acute pain.
| Ketorolac Tromethamine Class |
Analgesic |
| How Ketorolac Tromethamine Supplied |
Acular Solution 0.5%
Acular LS Solution 0.4%
Acular PF Solution 0.5% |
| Brand Name : |
Apo-Ketorolac , Apo-Ketorolac Injection , Novo-Ketorolac , Toradol IM |
Interaction and Contraindication of Ketorolac Tromethamine
Interaction of Ketorolac Tromethamine -
Aminoglycosides: Serum aminoglycoside levels may be increased.
Anticoagulants: May increase risk of gastric erosion and bleeding.
Aspirin, NSAIDs: Risk of inducing serious NSAID-related side effects. Concomitant use is contraindicated.
Furosemide: IM/IV may reduce the diuretic response about 20%.
Lithium: Serum lithium levels may be increased.
Methotrexate: May increase methotrexate levels.
Probenecid: May increase ketorolac plasma levels. Concomitant use is contraindicated.
Selective serotonin reuptake inhibitors (fluoxetine, paroxetine): Risk of GI adverse reactions may be increased.
Contraindication of Ketorolac Tromethamine -
Patients in whom ketorolac, aspirin, or any NSAID have caused hypersensitivity or allergic-type or reactions; active peptic ulcer disease; recent GI bleeding or perforation; advanced renal impairment and in patients at risk for renal failure because of volume depletion; suspected or confirmed cerebrovascular bleeding; hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding; history of peptic ulcer disease or GI bleeding; as prophylactic analgesia before any major surgery and intraoperatively when hemostasis is critical; for intrathecal or epidural administration; labor and delivery; lactation; concomitant use with aspirin or other NSAIDs; concomitant use with probenecid.
Side Effects o f Ketorolac Tromethamine
Here are the list of some common side effects ofKetorolac Tromethamine :
- Headache (17%); dizziness (7%); drowsiness (6%); sweating (greater than 1%); aseptic meningitis, convulsions, psychosis (postmarketing).
- Pruritus, rash (greater than 1%); exfoliative dermatitis, Lyell syndrome, maculopapular rash, Stevens-Johnson syndrome, urticaria (postmarketing).
- GI pain (13%); dyspepsia, nausea (12%); diarrhea (7%); constipation, flatulence, GI fullness, vomiting (greater than 1%); acute pancreatitis, esophagitis; GI hemorrhage/perforation, hematemesis, melena, peptic ulceration (postmarketing).
- Leukopenia, postoperative wound hemorrhage, thrombocytopenia (postmarketing).
- Asthma, bronchospasm (postmarketing).
- Injection site pain, purpura (greater than 1%); anaphylaxis/anaphylactoid reaction, angioedema, flank pain, laryngeal edema, myalgia, tongue edema (postmarketing).
Ophthalmic use: Allergic reactions (1% to 10%).
Precaution and Warning while taking Ketorolac Tromethamine
The precaution and warnings of Ketorolac Tromethamine drug is as follows:
- Inform patient that drug is an NSAID and can cause serious side effects, such as GI bleeding.
- Instruct patient to avoid alcohol, aspirin, and other NSAIDs.
- Advise patient to inform dentist and other health care providers of drug therapy before any treatment or surgery.
- Instruct patient to report the following symptoms to health care provider: black stools, edema, itching, persistent headache, skin rash, visual disturbances, or weight gain.
- Advise patient that drug may cause drowsiness or dizziness and to use caution while driving or performing other tasks requiring mental alertness.
- Instruct patient not to take any prescription or OTC medications, herbal preparations, or dietary supplements without consulting health care provider.
How to store Ketorolac Tromethamine
- The combined duration of ketorolac IV/IM and oral is not to exceed 5 days. Oral use is only indicated as continuation therapy to IV/IM.
- Do not mix IV/IM ketorolac in a small volume (eg, in a syringe) with morphine sulfate, meperidine hydrochloride, promethazine hydrochloride, or hydroxyzine hydrochloride; this will result in precipitation of ketorolac from solution.
- Lower doses may be necessary in patients with compromised renal or hepatic function.
- Store at room temperature (59° to 86°F). Protect from light.
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