Home :: Drugs ::Ifosfamide

Ifosfamide - Learn about Ifosfamide Side Effects and Precautions

Ifosfamide Information

The pharmacology action of Ifosfamide is that it ifosfamide requires metabolic activation by microsomal liver enzymes to produce biologically active metabolites. Enzymatic oxidation of the chloroethyl side chains and subsequent dealkylation produces the major urinary metabolites, dichloroethyl ifosfamide and dichloroethyl cyclophosphamide. The alkylated metabolites of ifosfamide interact with DNA.

Ifosfamide is used germ cell testicular cancer.

on coagulopathies (DIC); prevention of postoperative deep venous thrombosis (DVT), and PE.

Interaction and Contraindication of Ifosfamide

Interaction of Ifosfamide - Ifosfamide may increase the hypoprothrombinemic effect of warfarin.

Contraindication of Ifosfamide - Continued use in patients with severely depressed bone marrow function; hypersensitivity to ifosfamide.

Side Effects o f Ifosfamide

Here are the list of some common side effects ofIfosfamide :

• Somnolence; confusion; depression; hallucinations. CNS effects more common in patients with renal dysfunction, hypoalbuminemia, or receiving large single doses.
• Alopecia.
• Moderate potential for nausea and vomiting; elevated liver function tests.
• Hematuria, dysuria, urinary frequency; hemorrhagic cystitis, which can be prevented with the administration of mesna.
• Bone marrow suppression, nadir at 7 to 14 days.

Precaution and Warning while taking Ifosfamide

The precaution and warnings of Ifosfamide drug is as follows:

• Notify health care provider of the following: unusual bleeding/bruising; fever; chills; sore throat; cough; shortness of breath; seizures; lack of menstrual flow; unusual lumps or masses; flank, stomach, or joint pain; sores in mouth or on lips; yellow discoloration of skin or eyes.
• Contraceptive measures are recommended during therapy for men and women.

How to store Ifosfamide

• Reconstitute powder with sterile water for injection or bacteriostatic water for injection.
• Reconstitute 1,000 mg ifosfamide with 20 mL diluent for a final concentration of 50 mg/mL; 3,000 mg ifosfamide with 60 mL diluent for a final concentration of 50 mg/mL.
• Reconstituted 50 mg/mL solution may be further diluted to concentrations of 0.6 to 20 mg/mL with 5% dextrose, 0.9% sodium chloride, Lactated Ringer's solution, or sterile water for injection. Because stability is unchanged, other concentrations or mixtures of these solutions may be used, including 2.5% dextrose, 0.45% sodium chloride, or 5% dextrose with 0.9% sodium chloride.
• Ifosfamide, at a concentration of 100 mg/mL, is incompatible with bacteriostatic water for injection with benzyl alcohol. It is compatible at ifosfamide concentrations of up to 60 mg/mL.
• Solutions reconstituted with Bacteriostatic Water for Injection are stable for 1 wk at room temperature or 3 wk under refrigeration.
• Refrigerate solutions reconstituted with Sterile Water for Injection and use within 24 hr because they are preservative-free. The manufacturer recommends use within 6 hr of reconstitution.