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Home :: Drugs :: Galsulfase

Galsulfase- Learn about GalsulfaseSide Effects and Precautions

GalsulfaseInformation

The pharmacology action of Galsulfaseis that it Galsulfase is a glycoprotein that is intended to provide an exogenous enzyme that will be taken up into lyosome and increase the catabolism of glycosaminoglycans. This is most likely mediated by the binding of mannose-6-phosphate-terminated oligosaccharide chains of galsulfase to specific mannose-6-phosphate receptors

Galsulfaseis used in treatment of patients with mucopolysaccharidosis (MPS) VI

GalsulfaseClass Endocrine and metabolic agent
How GalsulfaseSupplied Naglazyme Solution for injection 1 mg/mL
Brand Name : Galsulfase

Interaction and Contraindication of Galsulfase

Interaction of Galsulfase- None well documented.

Contraindication of Galsulfase- Standard considerations.

Side Effects of Galsulfase

Here are the list of some common side effects of Galsulfase:

  • Areflexia, malaise (11%); headache.
  • Face edema (11%).
  • Abdominal pain (53%); gastroenteritis (11%); diarrhea; vomiting
  • Abdominal pain (53%); gastroenteritis (11%); diarrhea; vomiting
  • Rigors (21%); arthralgia.

Precaution and Warning while taking Galsulfase

The precaution and warnings of Galsulfasedrug is as follows:

  • Advise patient or caregiver that medication will be prepared and administered by a health care provider in a health care setting.
  • Advise patient or caregiver that reactions during infusion of galsulfase occur commonly and that medications may be given before the infusion in an effort to prevent or reduce the severity of these reactions.
  • Advise patient or caregiver that a surveillance program has been established to better understand the variability and progression of the disease and to monitor and evaluate the long-term treatment effects of galsulfase, including the effect of galsulfase on pregnant women and their children, and to determine if the medication is excreted in breast milk. Encourage patient to participate and advise them that their participation is voluntary and may involve long-term follow-up.
  • Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
  • Instruct patient not to take any prescription or OTC medications, dietary supplements, or herbal preparations unless advised by health care provider.
  • Remind patient or caregiver that therapy is administered once a week and to keep appointments.

 

 
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