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Home :: Drugs :: Famotidine
Famotidine - Learn about Famotidine Side Effects and Precautions
Famotidine Information
The pharmacology action of Famotidine
is that it
competitively blocks histamine at H 2 receptors, particularly those in gastric parietal cells, leading to inhibition of gastric acid secretion.
Famotidine is used in
short-term treatment of active duodenal ulcer; maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer; short-term treatment of active benign gastric ulcer; short-term treatment of gastroesophageal reflux disease (GERD, including erosive or ulcerative disease diagnosed by endoscopy); treatment of pathological hypersecretory conditions. IV is indicated in some hospitalized patients with pathologic hypersecretory conditions, intractable ulcers, or patients unable to take PO.
| Famotidine Class : |
Histamine H 2 antagonist |
| How Famotidine Supplied |
Pepcid Tablets 20 mg , Tablets 40 mg , Powder for Oral Suspension 40 mg/5 mL when reconstituted , Injection 10 mg/mL , Injection, pre-mixed 20 mg/50 mL in 0.9% NaCl
Pepcid AC Tablets, chewable 10 mg , Tablets 10 mg , Gelcaps 10 mg
Pepcid AC Maximum Strength Tablets 20 mg
Pepcid RPD Tablets 20 mg , Tablets 40 mg |
| Brand Name : |
Apo-Famotidine , Gen-Famotidine , Novo-Famotidine , Nu-Famotidine , Pepcid IV , ratio-Famotidine , Rhoxal-famotidine |
Interaction and Contraindication of Famotidine
Interaction of Famotidine -
Ketoconazole: Effects of ketoconazole may be decreased
Contraindication of Famotidine -
Hypersensitivity to other H 2 antagonists
Side Effects of Famotidine
Here are the list of some common side effects of Famotidine :
- Headache (5%); dizziness (1%); generalized tonic-clonic seizures, psychic disturbances, asthenia, fatigue.
- Toxic epidermal necrolysis (very rare); acne, alopecia, dry skin, flushing, pruritus, rash, urticaria .
- Diarrhea (2%); constipation (1%); abdominal discomfort, anorexia, dry mouth, nausea, vomiting.
- Agranulocytosis; leukopenia; pancytopenia; thrombocytopenia (rare).
- Anaphylaxis, angioedema, fever, orbital or face edema
- Arthralgia; musculoskeletal pain, including cramps
Precaution and Warning while taking Famotidine
The precaution and warnings of Famotidine drug is as follows:
- Advise patient using tablets or suspension to take prescribed dose without regard to meals, but to take with food if stomach upset occurs.
- Advise patient or caregiver using oral suspension to shake suspension vigorously for 5 to 10 sec before measuring dose and to measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
- Inform patient that antacids may be taken concurrently with famotidine.
- Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
- Instruct patient to report any of the following to health care provider: bloody or coffee ground vomit; black tarry stools; recurrent heart burn; recurrent indigestion or abdominal pain; increasing need for antacid use; bothersome side effects (eg, constipation, gas, headache).
- Instruct patient not to take any prescription or OTC medications, herbal preparations, or dietary supplements unless advised by health care provider.
- Advise patient that follow-up visits may be required to monitor therapy and to keep appointments
How to store Famotidine
- To prepare for IV push, dilute 2 mL famotidine (solution containing 10 mg/mL) with 0.9% Sodium Chloride for Injection in 5 to 10 mL volume. Administer over 2 min.
- To prepare IV infusion, dilute 2 mL famotidine (solution containing 10 mg/mL) with 100 mL 5% Dextrose. Other diluents that may be used include 0.9% Sodium Chloride for Injection, 10% Dextrose, Lactated Ringer's Injection, or 5% sodium bicarbonate. Infuse over 15 to 30 min.
- Keep premixed vials away from heat.
- Administer with antacids if necessary
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