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Edetate Calcium Disodium - Learn about Edetate Calcium Disodium Side Effects and Precautions

Edetate Calcium Disodium Information

The pharmacology action of Edetate Calcium Disodium is that Calcium is displaced by heavy metals, such as lead, to form stable EDTA complexes that are excreted in urine.

Edetate Calcium Disodium is used in treatment of acute and chronic lead poisoning and lead encephalopathy .

Interaction and Contraindication of Edetate Calcium Disodium

Interaction of Edetate Calcium Disodium - Not available

Contraindication of Edetate Calcium Disodium - Anuria; active renal disease; hepatitis

Side Effects of Edetate Calcium Disodium

Here are the list of some common side effects of Edetate Calcium Disodium :

• Renal tubular necrosis

Precaution and Warning while taking Edetate Calcium Disodium

The precaution and warnings of Edetate Calcium Disodium drug is as follows:

• Instruct patient to notify health care provider immediately if side effects occur.
• Explain rationale for strict I&O measurement and how to assist.
• Refer to public health agency regarding potential sources of lead poisoning and assistance for family in proper removal.
• Provide appropriate referrals for child who has learning deficits resulting from lead poisoning.
• Teach signs of lead poisoning, including metallic taste in mouth, abdominal cramping, GI upset, decreased urine output, alteration in mentation, blue-black line along gum, paresthesia, seizures, and coma. Instruct to notify health care provider if any of these signs appear.
• Counsel family in low-fat diet with adequate calcium, magnesium, zinc, iron, and copper to prevent binding and storage of lead in body.
• Review follow-up schedule of appointments to monitor serum lead levels.

How to store Edetate Calcium Disodium

• Use infusion pump to control rate of infusion. Infuse over 1 hr or more for asymptomatic adults. Infuse over 2 hr or more for symptomatic adults.
• Administer second daily infusion 6 hr or more after first dose.
• Administer IM if patient is child or has lead encephalopathy. Inject deep into well-developed muscle, and rotate injection sites. Use procaine or lidocaine to minimize pain at injection site.
• Administer dimercaprol in separate injection site if used concurrently with edetate calcium disodium.
• Administer in courses of 3 to 5 days, with second course given 2 days or more later if given IV or 4 days later if given IM.