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Echothiophate Iodide - Learn about Echothiophate Iodide Side Effects and Precautions

Echothiophate Iodide Information

The pharmacology action of Echothiophate Iodide is that it causes miosis, increase in facility of outflow of aqueous humor, fall in IOP, and potentiation of accommodation by enhancing the effect of endogenously liberated acetylcholine in the iris, ciliary muscle, and other parasympathetic innervated structures of the eye.

Echothiophate Iodide is used in treatment of chronic open-angle glaucoma; treatment of accommodative esotropia.

Interaction and Contraindication of Echothiophate Iodide

Interaction of Echothiophate Iodide - Cholinesterase inhibitors (eg, succinylcholine), organophosphate and carbamate insecticides:  The effects of these agents may be potentiated by echothiophate.

Contraindication of Echothiophate Iodide - Active uveal inflammation; most cases of angle-closure glaucoma because of the possibility of increasing angle block; hypersensitivity to any component of the product.

Side Effects of Echothiophate Iodide

Here are the list of some common side effects of Echothiophate Iodide :

• Cardiac irregularities.
• Activation of latent iritis or uveitis; brow ache; burning; conjunctival and ciliary redness; conjunctival thickening; induced myopia with visual blurring; iris cysts, which may obscure vision; lacrimation; lens opacities; lid muscle twitching; obstruction of nasolacrimal canals; paradoxical increases in IOP; retinal detachment; stinging.

Precaution and Warning while taking Echothiophate Iodide

The precaution and warnings of Echothiophate Iodide drug is as follows:

• Advise patient that usual dose is 1 drop in the affected eye(s) once or twice daily. Advise patient using 1 instillation/day to instill eye drops just before bedtime. Advise patient using 2 instillations/day to instill eye drops first thing in the morning and just before bedtime.
• Teach patient proper technique for instilling eye drops: Wash hands. Do not allow dropper tip to touch eye. Tilt head back, look up; pull lower eyelid down; instill prescribed number of drops. Close eye for 1 to 2 min and apply gentle pressure to bridge of nose for 1 to 2 min. Do not rub eye. Wash hands after instilling eye drops.
• Advise patient that if more than 1 topical ophthalmic drug is being used, administer the drugs at least 5 min apart.
• Inform patient that this medication may cause stinging, burning, tearing, eyelid muscle twitching, browache, eye redness, and blurred vision. Advise patient to notify eye doctor if any of these occur and are bothersome or intolerable.
• Instruct patient to immediately notify eye doctor if any of the following occur: eye or eyelid irritation; abnormal heart rhythm; excessive salivation; urinary incontinence; diarrhea; profuse sweating; muscle weakness; or respiratory difficulties.

How to store Echothiophate Iodide

• Do not touch tip of eye dropper to eye, fingers, or other surface.
• If using other topical ophthalmic drugs, separate each medication by at least 5 min.
• Store unopened bottles with powder for reconstitution in refrigerator (36° to 46°F). Reconstituted eye drops may be stored at controlled room temperature (77°F) for up to 4 wk. Discard any unused solution after 4 wk.