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Daclizumab - Learn about Daclizumab Side Effects and Precautions

Daclizumab Information

The pharmacology action of Daclizumab is that it binds with high-affinity to the Tac subunit of the high-affinity interleukin-2 (IL-2) complex and inhibits IL-2 binding, thereby impairing the response of the immune system to antigenic challenges. Daclizumab should be given by health care personnel trained in the administration of the drug and who have available laboratory and supportive medical resources.

Daclizumab is used in treatment of prophylaxis of acute organ rejection in patients receiving renal transplants.

Interaction and Contraindication of Daclizumab

Interaction of Daclizumab - Not Available

Contraindication of Daclizumab - Not Available

Side Effects of Daclizumab

Here are the list of some common side effects of Daclizumab :

• Hypertension, hypotension, aggravated hypertension, tachycardia (at least 5%).
• Tremor, headache, dizziness, insomnia (at least 5%); depression, anxiety (2% to less than 5%).
• Impaired wound healing without infection, acne (at least 5%); pruritus, hirsutism, rash, night sweats, increased sweating, application site reaction (2% to less than 5%)
• Constipation, nausea, diarrhea, vomiting, abdominal pain, pyrosis, dyspepsia, abdominal distention, epigastric pain (at least 5%); flatulence, gastritis, hemorrhoids (2% to less than 5%)
• Oliguria, dysuria, renal tubular necrosis (at least 5%); renal damage, hydronephrosis, urinary tract bleeding, urinary tract disorder, renal insufficiency, urinary retention (2% to less than 5%).
• Dyspnea, pulmonary edema, coughing (at least 5%); atelectasis, congestion, hypoxia, rales, abnormal breath sounds, pleural effusion (2% to less than 5%).
• Posttraumatic pain, chest pain, fever, pain, fatigue (at least 5%); shivering, generalized weakness, prickly sensation (2% to less than 5%).

Precaution and Warning while taking Daclizumab

The precaution and warnings of Daclizumab drug is as follows:

• Advise patient, family, or caregiver that medication will be prepared and administered by health care provider in a health care setting with close monitoring.
• Review dosing schedule with patient, family, or caregiver.
• Advise patient, family, or caregiver that medication will be used in combination with other agents, including cyclosporine and corticosteroids, to achieve max benefit possible.
• Instruct patient to continue to take other medications prescribed for preventing organ transplant rejection.
• Instruct patient to seek medical attention if any of the following occur: skin rash; hives; rapid heart beat; difficulty breathing; unexplained shortness of breath; fever, chills, or other signs of infection.
• Advise patient to notify health care provider if bothersome side effects occur.
• Caution patient that medication may cause dizziness or blurred vision and to use caution when driving or performing other tasks that require mental alertness, coordination, or physical dexterity until tolerance is determined.
• Caution women of childbearing potential to use effective contraception before starting therapy, during therapy, and for 4 mo following completion of treatment with daclizumab.
• Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.

How to store Daclizumab

• and corticosteroids.
• Concentrate must be diluted before administering to patient.
• For IV infusion only. Not for IV bolus, intradermal, subcutaneous, IM, or intra-arterial administration.
• Add prescribed amount of concentrate to 50 mL sterile 0.9% sodium chloride injection. Mix by gently inverting IV bag to avoid foaming. Do not shake.
• Discard any remaining concentrate in vial. Do not save unused concentrate for later use.
• Do not administer if solution is discolored, cloudy, or if particulate matter is noted.
• Administer infusion solution within 4 hr of preparation or within 24 hr if stored in refrigerator.
• Administer prescribed dose by IV infusion over 15 minutes. Dose is usually repeated q 14 days for total of 5 doses.
• Do not mix with other IV substances or additives or infuse simultaneously through the same IV line. If the same IV line is used for sequential infusion of different medications, flush line with saline solution.
• Store unopened vials in refrigerator (36° to 46°F). Do not freeze or shake. Protect from direct light. Diluted infusion solution is stable for 4 hr at room temperature or for 24 hr if refrigerated.