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Home :: Drugs :: Capreomycin
Capreomycin - Learn about Capreomycin Side Effects and Precautions
Capreomycin Information
The pharmacology action of Capreomycin
is that
it
interferes with protein synthesis
Capreomycin is used in
treatment
of tuberculosis concomitantly with other antituberculous agents.
| Capreomycin Class : |
Antituberculosis agent |
| How Capreomycin Supplied |
Capastat Sulfate Powder for injection 1 g (as sulfate)/vial |
| Brand Name : |
Capreomycin |
Interaction and Contraindication of Capreomycin
Interaction of Capreomycin -
Aminoglycosides (eg, streptomycin): May increase the risk of respiratory paralysis and renal dysfunction.
Nondepolarizing neuromuscular blocking agents (eg, tubocurarine): Neuromuscular blockade may be enhanced.
Contraindication of Capreomycin -
Not Available
Side Effects of Capreomycin
Here are the list of some common side effects of Capreomycin :
- Ototoxicity; hearing loss
- Nephrotoxicity.
- Leukocytosis; leukopenia; eosinophilia; thrombocytopenia.
- Decreased bromosulfophthalein excretion; abnormal liver function tests.
- Hypersensitivity (including febrile reactions, urticaria, maculopapular rash); pain; induration and excessive bleeding at injection site; sterile abscesses .
Precaution and Warning while taking Capreomycin
The precaution and warnings of Capreomycin drug is as follows:
- Advise patient that medication will be prepared and administered by a health care provider in a health care setting.
- Review dosing schedule and prescribed length of therapy with patient. Emphasize to patient that treatment will be lengthy.
- Instruct patient to report the following symptoms to health care provider: ringing in the ears, vertigo (feeling of whirling motion), dizziness, hearing loss, itching, rash, pain, lumps, bleeding at injection site.
- Instruct women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
- Instruct patient to not take any prescription or OTC medications or dietary supplements unless advised to do so by health care provider.
- Advise patient that follow-up visits and lab tests will be required to monitor therapy and to keep appointments.
How to store Capreomycin
- For IM or IV administration only. Do not administer intradermal or SC.
- Reconstitute following manufacturer's instructions.
- Inspect reconstituted solution visually before administration. Do not administer if solution is cloudy, discolored, or contains particulate matter. Reconstituted solution may acquire a pale straw color and darken with time, but this is not associated with loss of potency.
- For IM administration, give reconstituted capreomycin by deep IM injection into large muscle mass.
- For IV infusion, dilute reconstituted capreomycin in 100 mL of 0.9% Sodium Chloride injection and infuse prescribed dose over 60 min.
- Do not add other medications to IV container.
- Store powder for injection at controlled room temperature (59° to 86°F). Reconstituted solution may be stored for up to 24 hr in refrigerator (36° to 46°F).
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