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Candesartan Cilexetil - Learn about Candesartan Cilexetil Side Effects and Precautions

Candesartan Cilexetil Information

The pharmacology action of Candesartan Cilexetil is that it antagonizes the angiotensin II effect (vasoconstriction and aldosterone secretion) by blocking the angiotensin II receptor (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP.

Candesartan Cilexetil is used in treatment of hypertension.

Interaction and Contraindication of Candesartan Cilexetil

Interaction of Candesartan Cilexetil - Lithium:  Plasma concentrations may be increased by candesartan, resulting in an increase in the pharmacologic and adverse effects of lithium.

Contraindication of Candesartan Cilexetil - not available

Side Effects of Candesartan Cilexetil

Here are the list of some common side effects of Candesartan Cilexetil :

• Headache; dizziness; fatigue
• Rhinitis; sinusitis; pharyngitis
• Nausea; abdominal pain; diarrhea; vomiting
• Upper respiratory tract infection; bronchitis; cough
• Back pain; chest pain; edema; arthralgia; albuminuria

Precaution and Warning while taking Candesartan Cilexetil

The precaution and warnings of Candesartan Cilexetil drug is as follows:

• Inform patient that candesartan can control but does not cure hypertension.
• Caution patient to take the dose exactly as prescribed and not to stop taking the medication even if feeling better.
• Instruct patient not to decrease or increase the dosage without talking with health care provider.
• Inform patient of the following possible adverse effects: dry cough, renal function impairment, fetal injury.
• Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
• Instruct the patient in BP and pulse measurement skills. Caution patient to call health care provider should abnormal readings occur.
• Instruct patient that other methods of fall prevention, including rising slowly and sitting on the side of the bed before standing, especially early in therapy.
• Instruct patient of other medications, especially hypertensive medications, can have additive or synergistic effects. Have patient inform health care provider of all medication, including OTC drugs, presently being taking.
• Inform patient of the importance of adjunct therapies such as dietary planning, a regular exercise program, weight reduction, a low sodium diet, smoking cessation program, alcohol reduction, and stress management.
• Instruct patient to monitor renal, hepatic, and hematologic symptoms including urinary output and any discomfort during urination, weakness, fatigue, dizziness, lightheadedness, and jaundice. Patient should inform primary caregiver if symptoms occur.
• Warn patient that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting, resulting in reduced fluid volume, may lead to an excessive fall in BP, lightheadness, and possible fainting.
• Tell patient not to use potassium supplement or salt substitutes containing potassium to prevent possible hyperkalemia.
• Instruct patient to report any indications of an infection such as a sore throat, which could indicate neutropenia

How to store Candesartan Cilexetil

• Administer without regard to food.
• Check BP before administration.
• Anticipate a synergistic or additive effect with concomitant use of thiazides and other antihypertensive medications.
• Do not administer if patient is pregnant, breastfeeding, or otherwise contraindicated.
• Store at controlled room temperature (59° to 86°F) in a tightly closed container. Protect from moisture