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Basiliximab - Learn about Basiliximab Side Effects and Precautions
Basiliximab Information
The pharmacology action of Basiliximab
is that it
blocks the interleukin-2 receptor  -chain, which is a critical pathway in allograft rejection.
Basiliximab should be administered under qualified medical supervision experienced in immunosuppression therapy and management of organ transplantation.
Basiliximab is used in
prophylaxis of acute organ rejection in patients receiving renal transplantation when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.
| Basiliximab Class : |
Immunosuppressive |
| How Basiliximab Supplied |
Simulect Powder for injection 20 mg |
| Brand Name : |
Basiliximab |
Interaction and Contraindication of Basiliximab
Interaction of Basiliximab -
No data available
Contraindication of Basiliximab -
No data available
Side Effects of Basiliximab
Here are the list of some common side effects of Basiliximab :
- Hypertension; hypotension; angina pectoris; cardiac failure; abnormal heart sounds; arrhythmia; atrial fibrillation; tachycardia; vascular disorder
- Headache; tremor; dizziness; insomnia; hypoesthesia; neuropathy; paresthesia; agitation; anxiety; depression; fatigue; malaise
- Constipation; nausea; diarrhea; abdominal pain; vomiting; dyspepsia; moniliasis; enlarged abdomen; flatulence; gastroenteritis; GI hemorrhage; gum hyperplasia; melena; esophagitis; ulcerative stomatitis.
- Pain; chest pain; leg pain; back pain; asthenia; arthralgia; arthropathy; bone fracture; cramps; hernia; myalgia; hematoma; edema; peripheral edema; facial edema
Precaution and Warning while taking Basiliximab
The precaution and warnings of Basiliximab drug is as follows:
- Instruct patient or family to monitor for signs and symptoms of adverse events and report immediately to primary health care provider.
- Instruct family or patient to monitor for signs and symptoms of infections and transplant rejection including fever, pain, and urinary tract infections. Report these symptoms immediately to primary care provider.
- Advise women to notify health care provider immediately if pregnant, planning to become pregnant, or planning to breastfeed.
- Instruct women of childbearing potential to use effective contraception before beginning therapy, during therapy, and for 2 mo after the completion of therapy.
- Nursing mothers should discontinue nursing prior to using the drug.
- Stress the importance of regular exams and laboratory work.
- Encourage patient to comply with the treatment regimen.
How to store Basiliximab
- Store lyophilized basiliximab under refrigerated conditions at 2° to 8°C (36° to 46°F). The reconstituted solution can be refrigerated for 24 hr or at room temperature for 4 hr. Discard reconstituted solution if not used in 24 hr. Use the reconstituted solution immediately and dilute as directed.
- Inspect the bag for particulate matter or solution discoloration; do not use if present.
- Administer with care to assure sterility, as the solution contains no antimicrobial preservatives.
- Do not administer or add other drugs to the same bag or infuse simultaneously through the same IV line.
- Do not shake solution; invert bag gently to avoid foaming.
- Administer diluted solution through central or peripheral IV only over 20 to 30 min using sterile technique.
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